Publications

Publications

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63.
Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma: Christopher Lawson, Thowaiba Babikr Ahmed Alta, Georgia  Moschou, Vasiliki Skamnaki, Theodora G. A. Solovou, Caroline Topham, Joseph Hayes,* Timothy J. Snape,* Eur. J. Med. Chem., 2021, 225, 5, 113751.

62.
Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum: Erum Malik, David A. Phoenix, Timothy J Snape, Frederick Harris, Jaipaul Singh, Leslie H.G. Morton and Sarah R. Dennison,* Molecular and Cellular Biochemistry, 2021, doi.org/10.1007/s11010-021-04181-7.

61.
A therapeutic update on PARP inhibitors: implications in the treatment of glioma: Samridhi Lal and Timothy J. Snape, Drug Discovery Today2021, 26, 2, 532-541.

60.
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors: Ben A. Chetter; Efthimios Kyriakis; Daniel Barr; Aikaterini G. Karra; Elisabeth Katsidou; Symeon M. Koulas; Vassiliki T. Skamnaki; Timothy J. Snape; Anna-Maria G. Psarra; Demetres D. Leonidas; Joseph M. Hayes, Bioorganic Chemistry2020102, 1040032. 

59. 
Biophysical studies on the antimicrobial activity of linearized esculentin 2EM: Erum Malik; David A Phoenix; Leslie G Morton, Frederick Harris; Kamal Badiani; Timothy J. Snape; Jaipaul Singh; Sarah Rachel Dennison, BBA – Biomembranes20201862,2, 183141.

58.
Identification of C-β-D-glucopyranosyl azole type inhibitors of glycogen phosphorylase that reduce glycogenolysis in hepatocytes: in silico design, synthesis, in vitro kinetics and ex-vivo studies: Daniel Barr, Eszter Szennyes, Eva Bokor, Ziad H. Al-Oanzi, Colin Moffatt, Sandor Kun, Tibor Docsa, Ádám Sipos, Matthew P. Davies, Rachel T. Mathomes, Timothy J. Snape, Loranne Agius, Laszlo Somsak, Joseph M. Hayes, ACS Chem. Biol., 2019, 14, 7, 1460-1470.

57.
Towards Identifying Potent New Hits for Glioblastoma: Chris Sherer, Saurabh Prabhu, David Adams, Joseph Hayes, Farzana Rowther, Ibrahim Tolaymat, Tracy Warr and Timothy J. Snape*, MedChemComm, 20189, 1850-1861.

56. 
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells: Christopher Sherer, Ibrahim Tolaymat, Farzana Rowther, Tracy Warr, Timothy J. Snape*, Bioorg. Med. Chem. Lett.201727, 7, 1561-1565.

55.
Functional foldamers that target bacterial membranes: the effect of charge, amphiphilicity and conformation: Yogita Patil-Sen, Sarah R. Dennison and Timothy J. Snape*, Bioorg. Med. Chem., 201624, 4241-4245.

54.
Anionic host defence peptides from the plant kingdom: their anticancer activity and mechanisms of action: Frederick Harris, Saurabh Prabhu, Sarah R. Dennison, Timothy J. Snape, Robert Lea, Manuela Mura and David A Phoenix, Protein Pept Lett.201623(8), 676-87.

53.
Brain Tumours Deserve More: Timothy J. Snape, Pan European Networks – Horizon 20202016.

52.
Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications: Theodore J. Hester, Sarah R. Dennison, Matthew J. Baker and Timothy J. Snape,* Org. Biomol. Chem., 201513, 8067-8070.

51.
Foldamers as anticancer therapeutics: targeting protein-protein interactions and the cell membrane: Sara Fahs, Yogita Patil-Sen and Timothy J. Snape,* ChemBioChem201516, 13, 1840–1853.

50.
A Baker-Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides: Dana Ameen and Timothy J. Snape,* Tetrahedron Lett.201556, 1816–1819.

49.
Approaches Towards Improving the Prognosis of Paediatric Glioma Patients: Pursuing Mutant Drug Targets with Emerging Small Molecules: Timothy J. Snape* and Tracy Warr, Seminars in Pediatric Neurology201522, 28–34.

48.
Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: exploring the scope of indole and carbazole derivatives: Chris Sherer and Timothy J. Snape,* Eur. J. Med. Chem.201597, 552-560.

47.
Can the Rise of Foldamers Herald the Fall of Antibiotic Resistance?: Timothy J. Snape,* J Drug Des Res20141 (1), 1003.

46.
Mechanism and application of Baker-Venkataraman O→C acyl migration reactions: Dana Ameen and Timothy J. Snape,* Synthesis201447(02): 141-158.

45.
Aromatic amides and ureas as novel molecular probes for diagnosing disease: Samridhi Lal and Timothy J. Snape*, Medical Hypotheses201483, 751-754.

44.
Cn-AMP2 from green coconut water is an anionic anticancer peptide: Saurabh Prabhu, Sarah R. Dennison, Manuela Mura, Robert Lea, Timothy J. Snape and Frederick Harris, J. Pept. Sci., 201420, 909–915.

43.
Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity: Sara Fahs, Farjana B. Rowther, Sarah R. Dennison, Yogita Patil-Sen, Tracy Warr, Timothy J. Snape,* Bioorg. Med. Chem. Lett., 201424, 15, 3430–3433.

42.
A review of small molecule clinical trial candidates for the treatment of glioma: Saurabh Prabhu, Frederick Harris, Robert Lea and Timothy J. Snape,* Drug Discovery Today201419 (9), 1298-1308.

41.
Developing the scope of O→C aryl migrations; exploring amide substrates as potential precursors for new asymmetric reactions: Dana Ameen and Timothy J. Snape,* Eur. J. Org. Chem., 2014, 1925–1934.

40.
Towards a sustainable synthesis of aniline-derived amides using an indirect chemoenzymatic process: challenges and successes: Samridhi Lal and Timothy J. Snape,* RSC Adv.20144 (4), 1609 – 1615.

39.
Chiral 1,1-diaryl compounds as important pharmacophores: Dana M. Hamad Ameen and Timothy J. Snape,* Med. Chem. Commun., 20134 (6), 893 – 907.

38.
Synthetic oligoureas of metaphenylenediamine mimic host defence peptides in their antimicrobial behaviour: Sarah R. Dennison, David A. Phoenix, and Timothy J. Snape,* Bioorg. Med. Chem. Lett., 201323, 9, 2518–2521.

37.
Anionic antimicrobial and anticancer peptides from plants: Saurabh Prabhu, Sarah R. Dennison, Bob Lea, Timothy J. Snape, Iain D. Nicholl, Iza Radek and Frederick Harris, Crit. Rev. Plant Sci., 201332, 303–320.

36.
Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma: Saurabh Prabhu, Zaheer Akbar, Frederick Harris, Katherine Karakoula, Robert Lea, Farzana Rowther, Tracy Warr and Timothy Snape,* Bioorg. Med. Chem., 201321, 1918-1924.

35.
2-Arylindoles: a privileged molecular scaffold with potent, broad-ranging pharmacological activity: Samridhi Lal and Timothy J. Snape,* Curr. Med. Chem., 201219, 28, 4828-4837.

34.
Exploitation of a Candida antarctica lipase B-catalyzed in situ carboxylic acid activation method for the synthesis of acetanilides: Samridhi Lal and Timothy J. Snape,* J. Mol. Catal. B: Enzymatic201283, 80-86.

33.
Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes: Sarah R. Dennison, David A. Phoenix and Timothy J. Snape, Eur. Biophys. J., 201241, 8, 687-693.

32.
Exploiting conformationally restricted N,N’-dimethyl-N,N’-diarylureas as biologically active C=C double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues: Timothy J. Snape,* Katherine Karakoula, Farzana Rowther and Tracy Warr, RSC Adv., 20122, 19, 7557 – 7560.

31.
Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure: Andrea March-Cortijos, Timothy Snape* and Nicholas Turner, Synlett201223, 1511-1515. See also: Synfacts20128, 9, 0957.

30.
Interactions between suitably functionalised conformationally distinct benzanilides and phospholipid monolayers: Sarah R. Dennison, Zaheer Akbar, David A. Phoenix and Timothy J. Snape,*Soft Matter20128, 11, 3258 – 3264.

29.
Exploiting conformationally restricted ureas as biologically active C=C double bond analogues against GBM cells in vitro, TJ Snape, A Karakoula, F Rowther and TJ Warr, Neuro. Oncol., 201113 (suppl 2): ii1-ii14.

28.
Towards establishing the effects and mechanism of action of a series of indoles in an in vitro chemosensitivity system for glioma treatment, Saurabh Prabhu, Frederick Harris, Robert Lea and Timothy J Snape, Neuro. Oncol., 201113 (suppl 2): ii1-ii14.

27.
Understanding the chemical basis of drug stability and degradation: Timothy J. Snape*, Alison M. Astles and Janice Davies, The Pharmaceutical Journal2010, 285, 416.

26.
The process of drug development from the laboratory bench to the market: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal2010, 285, 272.

25.
The rational redesign of penicillins to help combat penicillin resistance: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal2010, 285,162.

24.
Take a close look at citalopram and you can predict its contraindications: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal2010, 285, 59 – Cover Article.

23.
Effects of Momordica charantia fruit extract with the combination of temozolamide and cisplatin in the treatment of glioma cancer: G. Manoharan, R. W. Lea, T. J. Snape, J. Singh*, Proc. Physiol. Soc., 2010, 18, PC22.

22.
Towards a chemo-enzymatic method for the asymmetric synthesis of β-amino tertiary alcohols: Andrea March-Cortijos and Timothy J. Snape*, Org. Biomol. Chem., 20097, 5163-5165.

21.
Versatility of a new bioinorganic catalyst: Palladized cells of Desulfovibrio desulfuricans and application to dehalogenation of flame retardant materials, K. Deplanche; T. J. Snape; S. Hazrati; S. Harrad; L. E. Macaskie*, Environmental Technology200930, 7, 681–692.

20.
Helix Persistence and Breakdown in Oligoureas of Metaphenylenediamine: Apparent Diastereotopicity as a Spectroscopic Marker of Helix Length in Solution: Jonathan Clayden*, Loic Lemiegre, Gareth A. Morris, Mark Pickworth, Timothy J. Snape and Lyn H. Jones, J. Am. Chem. Soc., 2008130, 15193–15202.

19.
α-Arylation of Aryl-Ketones: Expanding the Scope of the Truce-Smiles Rearrangement: Timothy J. Snape*, Synlett2008, 2689-2691.

18.
A Truce on the Smiles Rearrangement: Revisiting an Old Reaction – The Truce-Smiles Rearrangement: Timothy J. Snape*, Chem. Soc. Rev., 200811, 2452-2458.

17.
A biogenic catalyst for hydrogenation, reduction and selective dehalogenation in non-aqueous solvents: N. J. Creamer, K. Deplanche, T. J. Snape, I. P. Mikheenko, P. Yong, D. Samyahumbi, J. Wood, K. Pollmann, S. Selenska-Pobell and L. E. Macaskie*, Hydrometallurgy200894, 138-143.

16.
Enzymatic desymmetrisation of (2-hydroxymethyl-oxiranyl)-methanol in organic solvents: Andrea March Cortijos and Timothy J. Snape*, Tetrahedron: Asymmetry200819, 15, 1761-1763.

15.
Recent Advances in the Semi-Pinacol Rearrangement of α-Hydroxy Epoxides and Related Compounds: Timothy J. Snape*, Chem. Soc. Rev., 200736, 11, 1823-1842.

14.
A Template-Based Mnemonic for Monoamine Oxidase (MAO-N) Catalyzed Reactions and its Application Towards the Chemo-Enzymatic Deracemisation of the Alkaloid (±)-Crispine A: Kevin R. Bailey, Andrew J. Ellis, Renate Reiss, Timothy J. Snape* and Nicholas J. Turner*, Chem. Commun., 2007, 3640-3642. Designated a Chem. Commun. “Hot Article”

13.
Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N’-diarylureas and diaryl ethers: advantages of a relay axis: Mark S. Betson, Ann Bracegirdle, Jonathan Clayden*, Madeleine Helliwell, Andrew Lund, Mark Pickworth, Timothy J. Snape and Christopher P. Worrall, Chem. Commun., 20077, 754-756.

12.
Application of the Semi-Pinacol Rearrangement Towards the Generation of Alkenyl-Substituted Quaternary Carbon Centres: Timothy J. Snape*, Org. Biomol. Chem., 20064, 4144-4148.

11.
Induction of Apoptosis in Estrogen-Receptor Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IKK/NF-κB Pathway: Ciucci A, Gianferretti P, Piva R, Guyot T, Snape TJ, Roberts SM and Santoro MG*, Mol. Pharmacol.200670, 1812-1821.

10.
Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones: Dauvergne J, Happe AM*, Jadhav V, Justice D, Matos MC, McCormack PJ, Pitts MR, Roberts SM, Singh SK, Snape TJ, Whittall J, Tetrahedron200460, 2559-2567.

9.
Synthesis and revision of the stereochemistry of a cyclopentenone natural product isolated from ascomycete strain A23-98:Bickley JF, Roberts SM, Santoro AG, Snape TJ*, Tetrahedron200460, 2569-2576.

8.
The IκB kinase IKK is the molecular target for anti-herpetic cyclopentenones: Amici C, Belardo G, Ciucci A, Volpi C, Guyot T, Evans P, Happe A, Snape T, Roberts S, Santoro MG*, Antiviral Research200357, 3, A58-A58.

Book Chapters

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7.
Aromatic Rearrangements in which the Migrating Group Migrates to the Aromatic Nucleus. An Overview: Timothy J. Snape, Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds2016, Jacques Mortier (Ed.), Wiley. 

6.
Contributor to: Integrated Pharmacy Case Studies, Felicity J. Smith, Kevin Taylor, Sally-Anne Francis. 

5.
Monoamine Oxidase (MAO-N) Catalysed Reactions: Application Towards the Chemo-Enzymatic Deracemisation of the Alkaloid (±)-Crispine A: Andrew J. Ellis, Renate Reiss, Timothy J. Snape and Nicholas J. Turner, Practical Methods for Biocatalysis and Biotransformations2009, John Whittall, Peter Sutton (Eds), Wiley, Chapter 11.1.

4.
Chapter 10: Origins of Drug Molecules, Pharmaceutical Chemistry (Intergrated Foundations Of Pharmacy)2013, Chris Rostron, Jill Barber (Eds), OUP.

Patents

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3.
Timothy J. Snape, Patent Number: WO2014049364 A1, Publication Date: Apr 3, 2014, University Of Central Lancashire.

2.
Roberts Stanley Michael; Ross Nicolette Christa; Jadhav Vasudev; Evans Paul; Snape Timothy James; Happe Alan Michael; Santoro Gabriella Maria, Patent Number: AU2003224244, Publication Date: 2003-10-13, Charterhouse Therapeutics Ltd.

1.
Roberts, Stanley Michael; Santoro, Maria Gabriella; Jadhav, Vasudev; Happe, Alan Michael; Evans, Paul; Ross, Nicolette Christa; Snape, Timothy James, Patent Number: US 07759399, Publication Date: July 20, 2010, Crawford Healthcare Holdings Limited.

Talks

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University of Salford – Aromatic foldamers: past, present and future opportunities, Feb 2018 – Invited lecture.

University of Manchester – Glioma Chemotherapy: Opportunities and Challenges Using an Indole Scaffold, 24th May 2017 – Invited lecture.

University of Liverpool – Targeting the cell membrane with molecules that fold: exploiting the biological consequences of molecular origami, 20th May 2015 – Invited lecture.

Imperial College – APS Conference “Stimulating antimicrobial innovation” 22nd October 2015 – Targeting the bacterial cell membrane with synthetic molecules that fold: exploiting the biological consequences of molecular origami and geometry – Invited lecture.

De Montfort University – 23rd September 2015 – Folded for success: exploiting the biological consequences of molecular origami – Invited lecture.

RSC North-West Organic Division Regional Symposium: Targeting the cell membrane with molecules that fold: exploiting the biological consequences of molecular origami. University of Liverpool, 20th May 2015.

Gregynog Synthesis Workshop 2013, 12th-14th September.

Royal Society of Chemistry – Lancaster and District Section – The Urea Renaissance: Death to Infection? 16th April 2013.

BTNW – 6th/7th December 2012 – PDE1C: Molecular modelling and compound design – Invited lecture.

BTNW – 8th/9th December 2011 – Designing new molecules for the treatment of glioblastoma – Invited lecture.

BNOS 2011, University of Cambridge – Towards establishing the effects and mechanism of action of a series of substituted indoles in an in vitro chemosensitivity system for glioma treatment – 29th June – 1st July – Poster.

BNOS 2011, University of Cambridge – Exploiting conformationally restricted ureas as biologically active C=C double bond analogues against GBM cells in vitro – 29th June – 1st July – Invited lecture.

BTNW – 9th/10th December 2010.
University of Huddersfield – 14th April 2010 – Glioma Chemotherapy: Opportunities and Challenges – Invited lecture.